L-carnitine and Vitamin B Complex for PEG-L-asparaginase-Induced Hepatotoxicity
نویسندگان
چکیده
منابع مشابه
Successful treatment of pegaspargase-induced acute hepatotoxicity with vitamin B complex and L-carnitine.
Pegaspargase is a chemotherapy drug used in the treatment of acute lymphoblastic leukemia (ALL). One of the adverse effects of pegaspargase is hepatotoxicity, which can rapidly lead to liver failure and death. We report a patient with ALL who developed pegaspargase-induced severe hepatotoxicity that was rescued by treatment with vitamin B complex and L-carnitine. Our patient had a quicker respo...
متن کاملL-carnitine ameliorates L-asparaginase-induced acute liver toxicity in steatotic rat livers.
BACKGROUND Chemotherapy with L-asparaginase is associated with hepatotoxicity resulting in organ dysfunction in patients with preexisting liver disorders. This study investigated the protective effect of L-carnitine during chemotherapy in a steatotic rat liver model. METHODS Livers from nonsteatotic and steatotic rats were tested in an isolated liver reperfusion model adding L-asparaginase an...
متن کاملPEG-asparaginase induced severe hypertriglyceridemia.
Asparaginase (ASP) is an effective chemotherapy agent extensively used in children with acute lymphocytic leukemia (ALL). There has been a recent interest in using ASP in adults with ALL, particularly the less toxic pegylated (PEG) formulation. Hypertriglyceridemia (HTG) is a rare complication of PEG-ASP therapy. We report two cases of obese patients who developed severe HTG after receiving PEG...
متن کاملL-Asparaginase from escherichia coli B. Succinylation and subunit interactions.
Asparaginase from Esckerickio coli B has been modified with increasing amounts of [r4C]succinic anhydride. Enzyme activity is enhanced when 15 % and 25 % of the lysyl residues are succinylated. Up to 40% of the lysyl residues were succinylated without destroying enzyme activity and without causing dissociation of this oligomeric protein. More extensive succinylation causes dissociation into sub...
متن کاملComparison of pharmacokinetics of L-carnitine, acetyl-L-carnitine and propionyl-L-carnitine after single oral administration of L-carnitine in healthy volunteers.
PURPOSE To investigate the pharmacokinetics of L-carnitine (LC) and its analogues, acetyl-L-carnitine (ALC) and propionyl-L-carnitine (PLC) in healthy volunteers after single L-carnitine administration. METHODS Liquid L-carnitine (2.0 g) was administered orally as a single dose in 12 healthy subjects. Plasma and urine concentrations of L-carnitine, ALC and PLC were detected by HPLC. RESULTS...
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ژورنال
عنوان ژورنال: ACG Case Reports Journal
سال: 2019
ISSN: 2326-3253
DOI: 10.14309/crj.0000000000000194